Poly-(ADP-ribose) polymerases (PARPs), a super family of en-zymes, play important roles in preserving genomic integrity, regulating transcriptions, protecting telomeres and deter-mining cell fate.
It is now well established, based on randomized trials conducted in the general ICU adult and paediatric populations, that minimizing or avoiding sedation provides a better outcome, including shorter duration of mechanical ventilation and length of hospital stay.
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